Cancer Blog

There are several methods of treatment for mesothelioma although none of these have a high success rate. In general, the chances of curing a mesothelioma patient depends on how much the cancer has developed and matured when treated. If tackled aggressively in its early stages, there is a good chance of survival. Due to the difficulty of diagnosing mesothelioma in its early stages, many mesothelioma treatments focus on improving the quality of life for patients.

Before a patient is treated upon, a doctor will decide what the best course of treatment is by considering the patient’s age, medical history, general well being and even weight. From here, the doctor will decide which of the three most common treatments are most suited to the patient’s condition. These treatments are surgery, chemotherapy and radiation therapy.

Surgery

Surgery comes in two different types. Aggressive surgery is treatment which aims to gain long term control against the cancer and palliative procedures which aims to just relieve the patient of symptoms.

Aggressive surgery involves removing the pleura, the lung, the diaphragm and the pericardium. This procedure is known as extra pleural pneumonectomy. The aim of this is to remove as much of the tumour as possible without harming the patient. However, this is a very risky type of surgery and the chances are high of patient fatality within a month. Due to this, only young, fit individuals are referred to this form of treatment. Palliative procedures involve removing just the pleura in order to control the symptoms of the cancer. This is performed when mesothelioma is in an advanced form and is impossible to cure.

Chemotherapy

This is the most commonly known cure of cancer. Chemotherapy uses drugs to treat mesothelioma although many of these drugs have a poor success rate on patients. Combinations of drugs are often used to improve their effect. Some of these combinations have proved to be effective. Chemotherapy of mesothelioma is being improved regularly as research labs and pharmaceutical companies are discovering new and more effective drugs.

Radiation Therapy

Radiation therapy uses radiation to kill the tumour which mesothelioma creates. However, this procedure is extremely difficult because of where the tumour grows. Due to the closeness of the tumour and many vital internal organs such as the heart and lungs, doctors have to be very careful as to the doses of radiation they use. Lower radiation doses can be used however this lowers its effectiveness.

Dual Therapy

This is often used and is just a combination of surgery, chemotherapy and radiation therapy combined. Surgery removes the majority of the tumour cells while chemotherapy and radiation therapy work on removing the remainder. This is an effective method and also lessens the symptoms of the cancer.

The internal organs of the human body are encased in a protective sac called the mesothelium. Examples of mesothelilial membranes are the peritoneum (abdominal organs), pleura (lungs), and pericardium (heart).

Under specific conditions, the cells of the protective membrane divide uncontrolled and become cancerous. This disease is termed as Mesothelioma, a rare form of cancer which is caused by prolonged exposure to asbestos dust.

The disease is found to occur among those who work in shipyards, asbestos mines and factories, industries that produce asbestos based products, and the heating and construction businesses. Approximately 3,000 cases occur each year in the US, and most patients are between 50-70 years old. Statistics show that males are commonly affected and among them whites more than African Americans.

First studied in the late 1700s in depth studies were only done in the 1960s. Tumors of the Mesothelioma can be benign or malignant. The malignant Mesothelioma are categorized into three types:

• Epithelioid, accounting for 50-70% of mesotheliomas.

• Sarcomatoid, accounting for 7-20%.

• Mixed or bi-phasic, accounting for 20-35%.

When asbestos fibers are breathed into the lungs they travel through large air passages to reach the smaller passages and from them the pleura. In the pleura they damage: the mesothelial cells leading to cancer; lung tissue causing lung cancer; and the development of scar tissue within the lungs known as asbestosis. When asbestos fibers are swallowed they reach the abdominal cavity and cause peritoneal mesothelioma.

Research reveals that the disease only manifests 20-50 years after being exposed to asbestos dust. The symptoms are not specific to the disease but a patient may develop:

• Breathlessness.

• Chest pain accompanied by tightness believed to be caused by accumulation of fluid in the pleura.

• Low back pain.

• Swelling of face and arms.

• Sensory loss.

• Muscle weakness.

• Nausea.

• Vomiting.

• Weight loss that is unexplained.

• Persistent dry cough.

• Sore throat.

• Anemia.

• Fever.

• Constipation.

• Problems with blood clotting.

Since the above are common to minor ailments, patients often ignore the symptoms. It is advisable to consult a doctor if any of the above symptoms persist or if you feel you have been knowingly or unknowingly exposed to asbestos.

A doctor will:

• Take down a detailed medical history and try and determine the symptoms and risk factors.

• Do a thorough physical examination and check for signs of:

o Pleural effusion, fluid accumulated in the chest cavity.

o Fluid in the abdominal cavity.

o Pericardial effusion, fluid in the lining of the heart.

• Take a chest x-ray and check for thickening of the pleura, calcifications, and lowered lung fissures.

• Ask for a CT scan to determine clearly the location, size, and extent of the problem if any is suspected.

• Recommend tests of tissue samples and pleural fluids.

Other risk factors are cigarette or cigar smoking, exposure to radiation, exposure to zeolite a compound that is similar to asbestos, exposure to or infections caused by SV40, a Simian virus.

Those who work in a risky environment should wear protective clothing, have the surroundings tested regularly for suspended asbestos particles, and ensure that they have regular medical tests and report to the doctor any ailments that persist.

Being aware of the disease and its problems helps.